Asian Journal of Research and Reports in Urology

Epidemiological Prevalence and Molecular Markers of Bladder Cancer in Bangladeshi Women Aged 50-59: The Role of Tobacco Exposure and Awareness Deficits

Md. Masud Rana

Department of Public Health, First Capital University of Bangladesh,Chuadanga-7200, Bangladesh.

Sharmin Akter

Central Medical College, Cumilla-3500, Bangladesh.

Sazin Islam *

Department of Public Health, First Capital University of Bangladesh,Chuadanga-7200, Bangladesh.

Suzan Kumar Paul

Department of Public Health, First Capital University of Bangladesh,Chuadanga-7200, Bangladesh.

*Author to whom correspondence should be addressed.

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Abstract

Background: Bladder cancer represents a significant health concern worldwide. However, comprehensive studies on its epidemiological trends, molecular characteristics, and associated factors among Bangladeshi women have been scarce.

Methods: A sample of 1984 women was analyzed to assess epidemiological trends and molecular insights into bladder cancer. The study objectives encompassed epidemiological analysis, molecular characterization, risk factor assessment, quality of diagnosis and treatment evaluation, and exploration of educational and awareness initiatives. Sampling techniques involved stratified random sampling, ensuring representation across diverse demographic backgrounds.

Results: The age group 50-59 showed heightened bladder cancer prevalence. Molecular characterization highlighted the dominance of FGFR3 gene mutations, while a significant subset exhibited TP53 mutations. Tobacco smoke emerged as a primary risk factor. Although patient satisfaction concerning diagnosis and treatment was relatively high, there existed a noticeable lack of awareness regarding bladder cancer symptoms among the participants.

Conclusion: The study underscores the need for targeted awareness campaigns, enhanced early screening, and research-driven clinical interventions tailored for Bangladeshi women. The identified molecular markers also suggest opportunities for personalized therapeutic strategies. The findings call for a comprehensive approach in the healthcare sector to effectively tackle bladder cancer challenges among women in Bangladesh.

Keywords: Bladder cancer, epidemiological trends, molecular characterization, risk factors, Bangladesh women

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References

Smith JT, Rahman MS. Overactive bladder in women: global insights and regional variations. International Journal of Urological Research. 2018;14(3):112- 121.

Karim R, Siddiqui UA. Understanding the underpinnings of bladder dysfunction: A focus on the South Asian demographic. Asian Urology Today. 2019;23(2): 43-48.

Haque MA, Das S, Rahman M. Socioeconomic impact of urinary disorders in Bangladesh: An urban perspective. Journal of South Asian Medical Research. 2020;16(1):10-17.

Ahmed F, Choudhury SR. Evaluating the healthcare infrastructure: Case studies in urban Bangladesh. Bangladesh Health Journal. 2017;21(2):88-95.

Rashid M, Hasan MR. Prevalence and predictors of urinary incontinence among women: A community survey in Dhaka, Bangladesh. South Asian Journal of Community Medicine. 2018; 3(2):34-41.

Iqbal N, Rahman A. Quality of life assessment in women with overactive bladder: A qualitative study in Dhaka. Bangladeshi Journal of Psychiatry and Behavioral Sciences. 2020;14(1):23-28.

Alam MS, Hasan T. Public health campaigns and their impact on public awareness: A study on overactive bladder in Bangladesh. Public Health Review. 2017;12(3):115-122.

Chatterjee A, Mukherjee S. The impact of socio-cultural factors on the prevalence of bladder disorders in the South Asian region. Journal of Social Medicine. 2019;15(4):202-208.

Rahman MT, Ahmed SU, Chowdhury MA. Age-specific prevalence and risk assessment of bladder cancer in South Asia: An epidemiological review. Journal of South Asian Oncology. 2021;15(2):45-52.

Gupta PK, Hasan MR, Islam MN. Molecular characterization of FGFR3 mutations in early-stage urothelial carcinomas: Insights from Bangladesh. Bangladeshi Journal of Urology. 2022;28(1):11-18.

Rahman F, Khan SA, Reza SM. The role of TP53 mutations in bladder cancer progression and prognosis: A study of Bangladeshi cohorts. Asian Journal of Medical Sciences. 2020;11(4):67- 74.

Haque MS, Karim ME, Hasan TM. Tobacco consumption and its carcinogenic pathways leading to bladder cancer: A review in the Bangladeshi context. Journal of Public Health and Epidemiology. 2019;21(3):123-130.

Islam NF, Rashid MH, Chowdhury MA. Understanding the bladder lining: Impact of tobacco-derived carcinogens. Bangladeshi Journal of Physiology and Pharmacology. 2021;27(2):24-29.

Ahsan MM, Talukder MJ, Rahman MT. Delays in diagnosis and treatment of bladder cancer in Bangladesh: Impacts on prognosis and healthcare outcomes. Journal of Oncology Practice. 2020; 16(5):311-318.

Hossain MS, Uddin MN, Chowdhury MB. The efficacy of awareness campaigns in early detection of bladder cancer: A comparative study across Asian countries. Journal of Cancer Education. 2019;14(3): 560-567.

Faruque MO, Rahman S, Sultana SS. Integrating epidemiological data with molecular research for tailored interventions in bladder cancer: The way forward for Bangladesh. Journal of Clinical and Translational Research. 2022; 5(1):49-56.